Tag Archives: cochlear implant

cochlear implant

Cochlear implant electrodes improve hearing

Promising results have been reported from a world-first study of cochlear implant electrodes designed to stimulate hearing nerves and slowly release drugs into the inner ear.

HEARing Cooperative Research Centre (HEARing CRC) CEO Professor Robert Cowan said research using a cochlear implant electrode array that slowly releases anti-inflammatory drugs into the cochlear following implantation could lead to new benefits for cochlear implant users.

“The beauty of this approach is that it is based on use of the standard cochlear implant electrode array inserted into the inner ear that delivers sound sensations to the brain via the electrical stimulation of hearing nerve cells,” says Cowan. 

“The cochlear implant electrode array used in the research study was modified to slowly release a cortico-steroid after implantation.  This drug is intended to reduce inflammation and the growth of fibrous tissue around the electrode array triggered by the body’s immune response.”

After completing extensive biosafety studies, HEARing CRC researchers progressed to a study of the experimental electrode in ten adult patients, eight at the Royal Victorian Eye and Ear Hospital in Melbourne (RVEEH) and two at the Royal Institute for Deaf and Blind Children – Sydney Cochlear Implant Clinic (SCIC). 

 ENT surgeons Professor Rob Briggs and Professor Catherine Birman reported no compromise in surgical insertion characteristics with the experimental array.

Initial results confirm lower electrical impedance levels for the drug-eluting array patients, as compared with control groups from both clinics.  Impedance levels continue to remain lower 12 months post-implantation. 

“The suppression of the inflammatory reaction in the cochlear following electrode insertion is likely responsible for these lower impedance levels and may potentially contribute to preservation of an implant user’s residual hearing abilities when combined with slimmer electrode designs and newer surgical techniques,” Cowan explains. 

“Hearing preservation is important, as many candidates for cochlear implants have significant residual acoustic hearing, and want to be assured that they can use their residual acoustic hearing together with their cochlear implants.”

“Our hope is that this breakthrough will result in more people now considering cochlear implants as a viable way to manage their hearing loss”.

This drug-eluting electrode research has been made possible through the collaboration of Cochlear, RVEEH, and RIDBC-SCIC as members of the HEARing CRC, supported through the Commonwealth Governments CRC Programme.

“The HEARing CRC collaboration has contributed to commercial cochlear implant technologies that are now in world-wide use, as well as fitting technologies for both cochlear implants and hearing aids, helping to maintain Australia’s preeminent international standing in hearing research and service delivery,”  says Cowan. 

This article first appeared as a media release from the HEARing Cooperative Research Centre on 24 August 2016.

Innovating Australia

Australia faces a challenging period in shifting towards an ‘innovation economy’, with a drive towards greater participation in science and technology; an increased focus on commercialisation success; and partnering research with industry. But how will we get there?

In this unique series, leaders from government, industry and academia share their vision for Australia’s innovation future, including Australia’s Chief Scientist Alan Finkel, Telstra’s CTO Vish Nandlall, CEO of AusBiotech Anna Lavelle, entrepreneur, surgeon and inventor Fiona Woods, Chief Defence Scientist Alex Zelinksy, and the Vice Chancellors from QUT, Peter Coaldrake, and Western Sydney Uni Barney Glover, and many more.

Read the Thought Leadership Series: Australia’s Innovation Future, here. Commentaries will be published throughout the week.

The path forward

There is no doubt that Australian R&D often punches far above its weight for the size of the nation’s population. But for too long Australian invention has stalled at the crucial points in moving research from lab to marketplace. From a nation of thinkers, there has been too little product. Buoyed by the rich resources in the landscape, we have rested on our laurels, riding the sheep’s back or relying on our mineral wealth.

There are notable exceptions. Most Australians, for example, are familiar with the success of the cochlear implant, invented by Professor Graeme Clark and pioneered with a team of surgeons at Melbourne’s Royal Victorian Eye and Ear Hospital. This clever little device is now distributed in over 120 countries and has helped over 320,000 hearing-impaired patients. In the inaugural 2016 Top 25 Science Meets Business R&D spin-off list, this and other less familiar success stories – including companies just starting to make their mark – were noted and celebrated.

In December 2015, the Turnbull government pushed an agenda on innovation – the so-called #ideas boom. The innovation agenda clearly indicates that Australia must move from a resource-based economy to a knowledge-based economy. It highlights the poor track record of research commercialisation, and low rates of collaboration between industry and research organisations. The Organisation for Economic Cooperation and Development rates Australia as last or second last on the level of collaboration against other developed nations. So how much further forward does the ideas boom push us, and what more can be done?

The December 2015 agenda throws $1.1 billion towards steps to address stagnation in research commercialisation and business growth in STEM. This includes $200 million industry incentive to work with the CSIRO and Australian universities, and a 20% non-refundable tax offset for early stage investors. There’s also money for Australian businesses looking to relocate overseas, bonuses for universities collaborating and resources allocated towards raising awareness of the importance of STEM in education.

While the money sounds great, transitioning towards a knowledge economy is more than just a fiscal move – it requires a fundamental shift in the notion of what it is to be Australian. The pathway towards this mental reimagining is far from clear, and will involve people in business, education, research and communication industries to change their thinking, develop ideas and set in motion a totally different model of achievement.

In this thought leadership series, those stepping up to deliver on this challenge describe their vision of science, technology, engineering, maths, and medicine – in the way we do the research and in how we benefit from these fields – to describe their first step towards this brave new world. – Heather Catchpole

Read the Thought Leadership Series: Australian Innovation Future, here.

Contributors

Dr Alan Finkel AO, Chief Scientist of Australia

Dr Anna Lavelle, CEO and Executive Director of AusBiotech

Professor Peter Coaldrake AO, Vice-Chancellor of QUT

Dr Krystal Evans, CEO of the BioMelbourne Network

Professor Peter Klinken, Chief Scientist of Western Australia

Professor Barney Glover, Vice-Chancellor and President of Western Sydney University and Dr Andy Marks, Assistant Vice-Chancellor (Strategy and Policy) of Western Sydney University

Dr Cathy Foley, Chief of CSIRO’s Division of Materials Science and Engineering

Dr Alex Zelinsky, Chief Defence Scientist and Head of the Defence Science and Technology Group

Vish Nandlall, Chief Technology Officer of Telstra

Professor Fiona M Wood, FRACS AM, Director of the Burns Service of Western Australia and the Burn Injury Research Unit at the University of Western Australia

Everyday this week

John Pollaers, Chairman of the Australian Advanced Manufacturing Council

Robert Hillard, Managing Partner of Deloitte Consulting

Kim McKay AO, CEO and Executive Director of the Australian Museum

Philip Livingston, Founder and Managing Director of Redback Technologies

Leading the revolution

Cochlear implants have become synonymous with Australia’s innovation history. Inventor and surgeon Professor Graeme Clark put the first implant into patient Rod Saunders in 1978. Since then, Cochlear – the company that commercialised the cochlear implant – has been developing hearing products that improve the lives of hundreds of thousands of children and adults worldwide.

Today, Cochlear maintains its market competitiveness with aggressive R&D, research arrangements with 100 universities, and a strong leadership team. CRC partners have also helped maintain Cochlear’s position as world leader in implantable technology. For example, the Contour Advance Electrode array is now fitted to more cochlear implant patients worldwide than any other electrode design in the history of the field.

In return, the CRCs have gained access to a world-leading industry partner, and have helped contribute a value to Cochlear of approximately $120 million.

Cochlear’s Contour Advance Electrode is fitted to patients around the world.
Cochlear’s Contour Advance Electrode is fitted to patients around the world.

In April 2013, the CRC and Cochlear relationship entered a new era: the Australian Hearing Hub (AHH) at Macquarie University officially opened with an inaugural symposium managed by the HEARing CRC. The AHH
will provide the CRC with a Sydney base, as well as access to new facilities, including the world’s only magnetoencephalographic imager (MEG) that can be used with cochlear implant users to explore hearing centres in the brain, and how they adapt to cochlear implant hearing sensations. They have also developed a new 3D, real-world acoustic test environment.

“The potential impact for hearing health from this innovation worldwide is enormous.”

“This is a sensational example of what can be done through partnership,” says Associate Professor Jim Patrick, Chief Scientist at Cochlear Limited.


FAST FORWARD

Name: Cochlear Limited

HQ: Sydney

R&D: $500 million in 5 years (to 2014)

Reach: Africa, Europe, USA, Middle East, Asia-Pacific as of 2012

At a glance: Listed in 1995, Cochlear Limited is one of Australia’s most celebrated advanced manufacturing success stories. It employs 2700 people in 25 countries with manufacturing sites in Sydney, Sweden, Belgium and the US.

– Paul Hendy