Tag Archives: diabetes

wound healing

Wound healing clinic to change lives

A dedicated wound healing clinic – the first in Australia – opens on Tuesday, 7 March. It draws together a pool of specialist wound healing talent that includes a vascular surgeon, nurse practitioners, an advanced podiatrist and specialist wound nurses in one spot to treat and assess chronic wounds.

The clinic, Wound Innovations, is in Spring Hill, Brisbane and accessible to all Australians via the Spring Hill teleclinic, which connects patients and health professionals with a specialist from Wound Innovations through videoconferencing facilities. Wound Innovations also offers education for health professionals and will be a site for clinical trials and other research projects. 

Living with a serious wound is incredibly debilitating. “Wounds are painful and can exude a fluid. People with a wound can suffer from a lack of mobility and this leads to less social interaction, and isolation,” explains Dr Ian Griffiths, CEO of the Wound Management Innovation Co-operative Research Centre (CRC), which runs Wound Innovations.

“Often people are afraid to go out because of the smell from their wounds. It can take you down a very dark path.”

Dr Griffiths says there is medical research linking wounds with depression as well as dementia.

The teleclinic takes high resolution photos of each patient’s wounds to monitor progress and the patient provides feedback, while wound healing experts make recommendations for future care. Appointments may attract a Medicare rebate.

Griffiths expects the wound healing clinic and teleclinic to be a life changer for patients and plans to open other wound healing clinics with specialised teams in capital cities around Australia.

He also expects dramatic savings to the Australian healthcare system as fewer people with wounds will end up in hospital. The Wound CRC estimates that wound healing and management costs the Australian healthcare system $2.85 billion a year, but this is considered a conservative figure and one that covers only the tip of the iceberg.

Griffiths hopes big institutions such as aged and residential care homes will join the clinical service and teleclinic. Some have large percentages of residents who need constant, ongoing wound care. “I know of one aged care home with 38% of residents with chronic wounds,” says Griffiths.

Some of the worst wounds to treat stem from chronic diseases such as diabetes. There are more than 4400 amputations in Australia because of diabetic foot wounds and every 30 seconds a lower limb is lost around the world.

Funded by the Federal Government, the Wound CRC has carried out industry led research since 2010. One research project showed that 78% of patients with venous leg ulcers will heal over a 12-week period by using best practice wound care, including compression bandaging.

Patients in many of the CRC’s studies live with the ulcers for 10 to 20 years. In one case, a patient lived with ulcers for 54 years. At the time, Wound CRC was recruiting patients for a project studying wounds that did not clear up after 12 weeks.

The CRC’s extensive wound healing research stretching over seven years is helping the 433,000 Australian patients who are suffering from chronic wounds at any one time. Their research covers diabetic foot ulcers, burns, skin tears, acute surgical wounds and pressure injuries.

For more information visit woundinnovations.com.au or call 1300 968 637.

GSK Award

GSK Award for Research Excellence winners

Australian researchers exploring “dimmer switch” medicines that could help patients with obesity, diabetes and schizophrenia, have won the prestigious GSK Award for Research Excellence.

The ground-breaking research by Professors Arthur Christopoulos and Patrick Sexton from Monash University offers hope for people with chronic conditions. According to the researchers, medicines that can be “turned up” or “turned down” rather than “on and off“ will give doctors more variability to tailor treatment to a patient’s medical needs. Medicines based on this principle will allow patients to lead a more normal life without the side effects associated with existing drugs.

Their research into G protein-coupled receptors (GPCRs) has begun to unravel the complexities of drug action that could lead to more targeted medicines. The “dimmer switch” of a protein, known as the allosteric site, allows the targeted protein to be dialled up or down in a way that was not previously possible.

Both professors were congratulated on winning the GSK Award for Research Excellence at the annual Research Australia Awards in Sydney. The award is well recognised among the Australian medical research community and includes an $80,000 prize that will help the winners progress their work.

“Many medicines have unwanted side effects because they work by simply turning receptors on or off, even though we know that most of these proteins have the potential for more graded levels of response that can become highly relevant in the contexts of tissue specificity, disease and individual patient profiles. We have discovered a more tailored way to exploit this functionality, by targeting regions on the receptors that act more like dimmer switches rather than on/off switches,” says Sexton.

Both professors are world leaders in the study of G protein-coupled receptors (GPCRs), the largest class of drug targets, and the application of analytical pharmacology to understand allosteric modulation. In recent years their work has challenged traditional views of how medicines were thought to work.

“We have found molecules that can subtly dial up or dial down the effect of the receptor protein, or even ‘dictate’ which pathways it can or can’t signal to. This means we could in theory treat a range of diseases with this approach more effectively and safely by avoiding some of the side effects associated with standard on/off-type drugs.”

“Because an allosteric mechanism is more subtle and ‘tuneable’, medicines based on this principle can allow patients to lead a more normal life, especially those with chronic conditions,” says Christopoulos.

The GSK Award for Research Excellence is one of the most prestigious awards available to the Australian medical research community. It has been awarded since 1980 to recognise outstanding achievements in medical research with potential importance to human health.

Dr Andrew Weekes, Medical Director, GSK Australia, said GSK is proud to be able to support local researchers with the Award, now in its 36th year.

“The award has been given to some remarkable people over the years, many of whom are eminent academics in their field. GSK is honoured to support the research community and excited by their discoveries, which we believe will one day help patients,” says Weekes.

Professor Christopoulos said winning the GSK Award for Research Excellence is a great recognition of the efforts of all the scientists who have worked in this area over the years, often in the face of early scepticism.

“Science relies on the efforts and insights generated from dedicated people over many years. For us, this award is thus also an acknowledgement and testament to our colleagues, collaborators, students and postdocs who have helped us take a theoretical concept to the point where today we are creating a new paradigm in drug discovery,” says Christopoulos.

“This award will greatly assist us in progressing our research on allosteric modulation into new areas, and accelerate the possibility of helping patients suffering from a range of diseases that represent global health burdens but remain sub-optimally treated,” says Sexton.

Among the previous recipients of the GSK Award for Research Excellence are Australia’s most noted scientific researchers, including Professor Tony Basten (1980), Professor Nicos Nicola (1993) and Professor Peter Koopman (2007). The 2015 GSK Award for Research Excellence was awarded to James McCluskey (University of Melbourne) and Jamie Rossjohn (Monash University) for their research into the immune system.

This information on the GSK Award for Research Excellence was first shared as a media release by GSK on 17 November 2016. 

research startups

Research startups accelerate CSIRO science

Featured image above: Research startups pitch at the ON Accelerate demo night. Hovermap have developed intelligent software that will allow drones to map indoor environments.

There are now over 30 accelerator and incubator programs in Australia, but CSIRO’s ON accelerator is the only one focused on equipping research startups with the tools they need to grow.

“It’s the first time a program of this sort has been offered for the research community on this scale,” says Elizabeth Eastland, the General Manager for Strategy, Market Vision and Innovation at CSIRO.

Just six months ago, Eastland was the Director of the University of Wollongong’s iAccelerate program, but moved to CSIRO having been “blown away by what this program can offer researchers”.

At the ON Accelerate Demo event held on Thursday 7 July, Eastland introduced 11 research startups who pitched their products to Sydney’s venture capital investors. In contrast to the young faces that dominate many of Australia’s accelerators, last night’s ON cohort were led by experienced researchers, engineers, developers and entrepreneurs.

Two of the research startups revealed big plans for the agriculture industry. A group called Future Feed is selling seaweed supplements that aim to reduce livestock greenhouse gas emissions by 80%. Another team has created wireless trapping technology to help farmers detect fruit fly infestations.

Fruit Fly costs farmers US$30 billion in fruit and vegetable production around the world, but this isn’t the only global challenge that the ON research startups have been tackling. The presenter from Modular Photonics pointed out last night that the world’s internet demand is about to outstrip its fibre capacity.

His group is commercialising new photonics hardware compatible with both old internet fibre and the new fibre being developed by the top telecommunications providers.

On the health front, another of the research startups, ePAT unveiled new facial recognition software to detect pain levels in people who cannot speak, such as children and elderly people with moderate to severe dementia. Their vision is that “no patient who cannot speak will suffer in silence in pain”.

ON Accelerate had major success earlier this year when a German company launched a gluten free beer brewed from barley commercialised by a startup from last year’s ON cohort. That startup, known as Kebari, is in now the process of developing another form of gluten free grain for use in food.

Kebari co-founder and scientist Dr Phil Larkin spoke at yesterday’s research startups event, saying ON Accelerate had taught him about ‘flearning’ – learning from failure – and the importance of interrogating the entire delivery chain to validate the value of a solution.

CSIRO Principal Research Scientist and RapidAIM team leader Dr Nancy Shellhorn said that the program had given her much faster access to the market and much better insight into customer needs.

“It’s given me and the RapidAIM team a runway to the science of the future that will be truly impactful,” said Shellhorn.

Program Mentor Martin Duursma also spoke at the research startups event, saying that startup skills are very transferable to research teams because they are all about trying something, gathering feedback, making improvements and repeating the process.

“Startup skills are really just a variant of the scientific method,” said Duursma.

And scientists will have greater access to the ON research startups program next year, with a dramatic increase in the interest of universities. Eastland says that 21 of Australia’s 40 universities have now signed on to be ON partners. Macquarie University and Curtin University led the pack with their involvement this year. UNSW Australia, the University of Technology Sydney and Monash University are among those jumping on board for the next round.

– Elise Roberts


ON Accelerate Research Startups

The below information was first shared by CSIRO. Read the original list and team members here.

1. Hovermap

The future of asset inspection.

“Every year, Australia loses billions of dollars due to infrastructure failures, spends billions of dollars on inspecting its aging assets and loses some of its bravest men and women who take the risk to do this dull and dangerous job. Utility companies and governments are turning to Unmanned Aerial Vehicles (UAVs) to reduce costs and improve safety. However, current UAVs are ‘dumb and blind’ so require expert pilots and can’t fly in many places.

Our solution is an intelligent UAV with advanced collision avoidance, non-GPS flight and accurate 3D mapping capabilities – all tailored to suit industrial inspection requirements. Hovermap is the ultimate inspection tool of the future that can be used to safely and efficiently inspect hard-to-reach assets and collect extremely high fidelity data in previously unreachable places. It is suitable for inspecting telecommunication towers, bridges, power line assets and smoke stacks. This innovative technology will reduce risks, improve safety and efficiency and lower costs, all of which benefit customers and businesses.”

2. Suricle

Changing the face of polymers.

“We change the face of polymers by embedding functional particles into the surface to give them new and useful properties. Our patented technology paves the way for development of many new, innovative materials and products.

An immediate area of application is to protect high-value marine sensors from biofouling. The unwanted growth of marine organisms causes signal attenuation, sensor malfunction, increased weight and unwanted drag due to ocean currents. There are many thousands of marine sensors deployed globally, costing up to $120K each, which require frequent cleaning to keep them in service.

Suricle are focusing on treating adhesive polymer films with antifouling properties for attachment to sensors to mitigate biofouling. Kits containing this film will be sold via our e-commerce store for application in the field by the end-users, offering savings of thousands of dollars per year in reduced maintenance costs.”

3. RapidAIM

Supporting and growing global fruit and vegetable export markets

“Fruit Fly are the number one biosecurity issue in fruit and vegetable production. Globally US$30b worth of fruit and vegetable production is lost due to fruit fly, and $US18b in global trade is threatened by the pest.

Millions of fruit fly traps across the globe are checked manually, causing delay and risking outbreaks. This can close markets!

RapidAIM is a new era in biosecurity. We provide a service of real-time alerts for the presence and location of fruit fly using wireless trapping technology. This immediate data-driven decision service allows biosecurity agencies, growers and agronomists to respond rapidly to fruit fly detection to control the pest.

This allows for targeted workflow, the protection of existing markets and supports the development of new trading opportunities.”

4. ExByte

Predictive data analytics for preventative maintenance of infrastructure assets including water 

“Each year 7,000 critical water main breaks occur in Australia resulting in billions of dollars in rectification and consequence cost. In contrast, the cost of preventative maintenance is only 10 per cent of the reactive repair cost. The ExByte team has developed a disruptive technology that uses data analytic techniques to predict failure probability based on learned patterns, offering a solution to accurately predict water pipe failures resulting in effective preventative maintenance and a reduction in customer interruptions.”

5. Future Feed

A natural feed additive from seaweed that dramatically reduces livestock methane and increases production.

“The world is under increasing pressure to produce more food and producing more food is contributing to climate change. Livestock feed supplementation with FutureFeed is the solution. It can improve farm profitability and tackles climate change. FutureFeed can also provide farmers access to other income streams through carbon markets and provide access to premium niche markets through a low carbon footprint and environmentally friendly product.”

6. elumin8

An energy efficiency product that empowers households to understand and reduce their energy consumption.

“It is very difficult for households to improve their energy efficiency and transition to a sustainable future as current solutions are boring, costly and confusing. Elumin8 solves this problem by providing tailored energy information via a unique communication channel, allowing homeowners to directly engage with their home in a human and personable way as though it was another member of the family. Elumin8 also guides the household step by step along the journey to energy independence by improving energy efficiency and taking the risk and confusion out of installing solar and batteries.

We do this by collecting electricity data from a single sensor and use unique algorithms to disaggregate the data and determine appliance level consumption. Social media applications and advanced analytics are then utilised to connect the homeowner with their home allowing instant and humanised communication to ensure they are engaged with their energy use.”

7. Coviu

An online face-to-face business transaction platform.

“The way we work is changing. We need tools to enable those changes.

Traditional video conferencing tools are clunky and do not support experts like coaches, clinicians or lawyers in delivering and charging for their professional services online.

Coviu is the solution. Professionals get a frictionless and easy-to-use solution for setting up online consulting rooms and invite clients to rich interactive consults. One click and your client is talking to you in their browser – no software installations, no complicated call setup.

Coviu is a groundbreaking new video and data conferencing technology that works peer-to-peer allowing for massive scalability, speed and affordability.”

8. Reflexivity

A process that helps mining companies proactively manage community sentiment before conflict occurs.

“When resources companies lose the trust of the communities they work alongside, conflict occurs. Projects take twice as long to develop as they did a decade ago and cost 30 per cent more than they should because of social conflict. Companies don’t have the tools to systematically understand what their communities think about them, and communities have few constructive ways to feel heard.

Reflexivity has solved this problem by providing our customers with a sophisticated data analytic engine that translates community survey data we collect into prioritised opportunities for trust building and risk mitigation strategies. Our analytics identify those factors that build and degrade trust in a company, in the minds of community members; our customers are then able to invest resources and energy into the issues that matter most. Using mobile technology, our data streams to our customers in real time via a subscription model.

We have engaged over 14,000 community members in eight countries, and generated $1.5m in revenue in the last three years. And while we started in mining, our process is valuable wherever these relationships are important. We are building a service delivery platform to scale up our process and we are seeking support and advice to turn our successful global research program into a successful global business.”

9. Meals by Design

Healthy convenience never tasted so good!

“Ready-to-eat convenience doesn’t have to result in dissatisfaction and guilt. By bringing together the latest innovations in food manufacturing, including High Pressure Thermal processing, and an understanding of the nutritional needs of a diverse population, cuisine favourites can be prepared in a convenient format without compromising eating satisfaction or, importantly, nutrition.

Meals by Design develops premium and customisable meal solutions that cater to nutritional and functional needs, offering healthy convenience without compromise.”

10. ePAT

Real-time pain assessment through facial recognition technology for patients that cannot verbally communicate.

“Imagine you are in excruciating pain, but you can’t tell anyone. This is the reality for millions of non-communicative people world-wide, such as those with moderate to severe dementia. ePAT’s point of care apps utilise facial recognition technology to detect facial micro-expressions which are indicative of pain, to provide these people with a voice.”

11. Modular Photonics: big fast data

Passive fibre-optic technology that significantly increases data transmission capacity.

“Modular Photonics uses a novel integrated photonic chip to enhance the data rate across existing multimode fibre links by 10x and more. The technology enables multiple data channels in parallel without the length restrictions imposed by conventional multimode fibre links.”

Smart sole support for diabetic feet

Experts from the Wound Management Innovation CRC, based at the Queensland University of Technology (QUT) in Brisbane, said a shoe insole that communicates with the wearer’s phone could prevent foot injuries among diabetics.

Diabetes is one of the fastest growing diseases globally, with the number of people living with diabetes worldwide set to grow from 382 million in 2013 to 592 million by 2035, according to Diabetes Australia. Poor blood glucose control among diabetics can cause nerve damage to feet and inhibit blood supply. This results in an absence of sensation in the feet, which can lead to serious foot injury.

200115_woundmgmt_box2The CRC is about to start a patient trial of an insole made using pressure-sensing fabric that sends a message to a smartphone warning of potential damage to a diabetic’s feet.

The pressure-sensitive fabric was originally developed at RMIT University for elite athletes. It has since been fine-tuned in consultation with experts in podiatry from Southern Cross University.

Electronics in the insole will pick up changes in the distribution of pressure applied in each step, which are indicative of a wearer subconsciously favouring a foot or part of a foot. The electronics will then communicate wirelessly to the wearer’s smartphone at the point where the patient is at risk of foot damage.

Diabetics are prone to minor breaks in the skin of the foot, which can lead to ulcers. Patients with a history of these ulcers have a high risk of the problem recurring, so the trial will initially determine if the technology can reduce the recurrence of skin breaks. An ulcer on the bottom of the foot can develop into an injury that penetrates to the bone and can cause chronic infections, open sores and eventually result in amputation.
CRC Chief Executive Officer Dr Ian Griffiths said the technology had the potential to reduce the incidence of ulcer recurrence among people living with diabetes, saving them from severe pain, possible amputation and incapacity.

200115_woungmgmt_box“Diabetics have to be very careful of foot injuries. An injury can cause months of pain and anguish. It can keep diabetics off their feet and stop them going to work, doing the shopping – generally leading a normal life.”

The CRC initiative involves QUT, Southern Cross University, RMIT and its industrial partner Smith & Nephew as an advisor.

The CRC, funded until July 2018, is working with similar organisations in Canada and Wales to leverage strengths in scientific and clinical research and education through an International Wound Management Research Collaboration. The project will focus on a postgraduate student exchange program and establish the International Registry of Wounds.

www.woundcrc.com