Brain teaser: 3D-printed ’tissue’ to help combat disease

August 05, 2015

Researchers 3D print artificial brain tissue to investigate the effect of drugs and explore brain disorders.

The brain is amazingly complex, with around 86 billion nerve cells. The challenge for researchers to create bench-top brain tissue from which they can learn about how the brain functions, is an extremely difficult one.

Researchers at the ARC Centre of Excellence for Electromaterials Science (ACES), based at UOW’s Innovation Campus, have taken a step closer to meeting this challenge, by developing a 3D-printed layered structure incorporating neural cells, that mimics the structure of brain tissue.

The value of bench-top brain tissue is huge. Pharmaceutical companies spend millions of dollars testing therapeutic drugs on animals, only to discover in human trials that the drug has an altogether different level of effectiveness. We’re not sure why, but the human brain differs distinctly from that of an animal.

A bench-top brain that accurately reflects actual brain tissue would be significant for researching not only the effect of drugs, but brain disorders like schizophrenia, and degenerative brain disease.

ACES Director and research author Professor Gordon Wallace (pictured above with Rodrigo Lozano and Elise Stewart) said that the breakthrough is significant progress in the quest to create a bench-top brain that will enable important insights into brain function, in addition to providing an experimental test bed for new drugs and electroceuticals.

“We are still a long way from printing a brain but the ability to arrange cells so as they form neuronal networks is a significant step forward,” says Wallace.

To create their six-layered structure, researchers developed a custom bio-ink containing naturally occurring carbohydrate materials. The custom materials have properties that allow accurate cell dispersion throughout the structure, whilst providing a rare level of protection to the cells.

The bio-ink is then optimised for 3D-printing, and developed for use in a standard cell culturing facility without the need for expensive bio-printing equipment.

The result is a layered structure like brain tissue, in which cells are accurately placed and remain in their designated layer.

“This study highlights the importance of integrating advances in 3D-printing, with those in materials science, to realise a biological outcome,” says Wallace.

“This paves the way for the use of more sophisticated printers to create structures with much finer resolution.”

The research, funded through Wallace’s Australian Laureate Fellowship, is published in Biomaterials

This article was first published on 3 August 2015 by the University of Wollongong. Read the original article here.

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10 thoughts on “Leading sustainable design”

    1. Thanks Jeff! We’re going to publish interviews with the leaders of some of the top 25 companies over the course of the week – keep an eye out!

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  2. I’m not sure I read the article properly as I suffer from presbyopia – anyone doing anything about this condition?

  3. I’ve been curious about the different uses of contact lenses. I think it’s so interesting that they are developing smart contact lenses! I love the idea of technology like this. I can’t wait to see how it progresses! Thanks for sharing!

    1. Thanks for the great comment Braden! We can’t wait to see the future of this awesome technology too. Did you see some of the weird and wonderful tech in sciencemeetsbusiness.com.au/big-data-big-business/? Umbrella rain sensors, pigeon pollution monitoring. Keep in touch! SMB

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